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This is because Cardarine will allow us to lose fat very effectively and Ostarine will make us keep our muscle mass during a cut." But for most clients who aren't looking to lose fat, neither drug has proven to be effective. The problem: A number of people have tried both medications and say they haven't been successful. One doctor described the experience of a client who gave up Cardarine. "In the end, she didn't lose any weight at all…and was even more overweight. So that's what you really want to test and see if an improvement occurs." Dr. Thomas said that "to get a full picture of what is going on with the system, we need both drugs. The question is: is that effective enough?" Related Article: